Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5071
Title: Preparation and characterization of n-dodecyl-ferulate-loades solid lipid nanoparticles (SLN).
Authors: Souto, E. B.
Anselmi, Cecilia
Centini, Marisanna 
Muller, R. H.
Keywords: n-Dodecyl-ferulate; Solid lipid nanoparticles; SLN; Sunscreens
Issue Date: 2005
Project: None 
Journal: INTERNATIONAL JOURNAL OF PHARMACEUTICS
Abstract: 
Solid lipid nanoparticles (SLNTM ) containing a novel potential sunscreen n-dodecyl-ferulate (ester of ferulic acid) were developed. The preparation and stability parameters of n-dodecyl-ferulate-loaded SLN have been investigated concerning particle size, surface electrical charge (zeta potential) and matrix crystallinity. The chemical stability of n-dodecyl-ferulate at high temperatures was also assessed by thermal gravimetry analysis. For the selection of the appropriated lipid matrix, chemically different lipids were melted with 4% (m/m) of active and lipid nanoparticles were prepared by the so-called high pressure homogenization technique. n-Dodecyl-ferulate-loaded SLN prepared with cetyl palmitate showed the lowest mean particle size and polydispersity index, as well as the highest physical stability during storage time of 21 days at 4, 20 and 40 ◦C. These colloidal dispersions containing the sunscreen also exhibited the common melting behaviour of aqueous SLN dispersions.
Description: 
37572
URI: http://hdl.handle.net/20.500.12779/5071
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2005.02.005
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