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|Title:||Helicobacter pylori immunoproteomes in case reports of rosacea and chronic urticaria.||Authors:||Mini, R
DI SIMPLICIO, F
|Keywords:||Helicobacter pylori; immunoglobulins; immunoproteome||Issue Date:||2005||Project:||None||Journal:||PROTEOMICS||Abstract:||
Rosacea and chronic urticaria are two common skin disorders existing in idiopathic forms. A role of Helicobacter pylori bacterium infection in the aetiopathogenesis of rosacea or chronic urticaria has been suggested although still controversial. The aim of the present study was to establish a relationship between H. pylori infection and rosacea chronic urticaria by means of an immunoproteomic investigation. We analyzed immunoglobulin A (IgA)-, IgG-, and IgE-mediated immune-responses against H. pylori antigens and we identified some bacterial immunoresponsive proteins. A general IgA- and IgE-mediated immune response against antioxidative bacterial proteins was observed. A correlation between the bacterial occurrence and skin diseases pathogenesis is discussed.
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