Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5062
DC FieldValueLanguage
dc.contributor.authorM., Jezowska Bojczuken_us
dc.contributor.authorW., Szczepaniken_us
dc.contributor.authorMangani, Stefanoen_us
dc.contributor.authorGaggelli, Elenaen_us
dc.contributor.authorGaggelli, Nicolaen_us
dc.contributor.authorValensin, Giannien_us
dc.date.accessioned2021-03-30T15:48:46Z-
dc.date.available2021-03-30T15:48:46Z-
dc.date.issued2005-
dc.identifier.issn1434-1948en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/5062-
dc.description47933en_US
dc.description.abstractProtonation and copper(II) coordination properties of neomycin B were studied in solution by potentiometry, NMR, UV/Vis, CD, and EPR spectroscopy, XAS and mass spectrometry. Mono- and dinuclear complexes were found depending on the metal-to-ligand molar ratio. Neomycin B anchors CuII ions above pH 5.0 with an NH2 group from ring B. Simultaneously, the second amino group of the same ring and the hydroxyl group of ring A complete the binding set of donors. With an increase in pH the remaining –NH3+ functional groups in the neomycin B molecule are deprotonated without affecting the complexation pattern. However, these groups, particularly the ones located in the D-ring of the antibiotic, may coordinate the second copper(II) ion when the metal is present in excess. We have proved this process with the use of potentiometry, CD and especially mass spectrometry.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofEUROPEAN JOURNAL OF INORGANIC CHEMISTRYen_US
dc.subjectXAS; NMR; UV/vis; CD; antibiotic; copperen_US
dc.titleIdentification of copper(II) binding sites in the aminoglycosidic antibiotic Neomycin Ben_US
dc.typeArticleen_US
dc.identifier.doi10.1002/ejic.200500102en_US
dc.identifier.scopus2-s2.0-23744510668en_US
dc.identifier.isiWOS:000231340900013en_US
dc.relation.volume2005en_US
dc.relation.issue15en_US
dc.description.firstpage3063en_US
dc.description.lastpage3071en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0003-4824-7478-
crisitem.author.orcid9810-
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