Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5054
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dc.contributor.authorLongini, Mariangelaen_us
dc.contributor.authorPerrone, Sen_us
dc.contributor.authorKenanidis, Aen_us
dc.contributor.authorVezzosi, Pen_us
dc.contributor.authorMarzocchi, Barbaraen_us
dc.contributor.authorPetraglia, Feliceen_us
dc.contributor.authorCentini, Gen_us
dc.contributor.authorBuonocore, Giuseppeen_us
dc.date.accessioned2021-03-30T15:48:42Z-
dc.date.available2021-03-30T15:48:42Z-
dc.date.issued2005-
dc.identifier.issn0891-5849en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/5054-
dc.description35104en_US
dc.description.abstractIsoprostanes are markers of free radical-catalyzed lipid peroxidation. Evidence suggests that oxidative stress occurs in pregnancies with fetal growth restriction (FGR). The aim of this study was to analyze F2-isoprostanes in amniotic fluid of FGR pregnancies. We tested the hypothesis that F2-isoprostanes are reliable markers to distinguish FGR pregnancies from normal ones and appropriate-for-gestational-age (AGA) from small-for-gestational-age (SGA) newborns. F2-isoprostanes levels were measured by colorimetric enzyme immunoassay in the amniotic fluid of 77 pregnancies with normal fetal growth (group I) and 37 with FGR (group II). Fetal biometry and Doppler measurements were obtained using an ATL HDI 3000 ultrasound system. Isoprostanes were higher in group II than group I. The ROC curve distinguished group I from group II, showing 100% sensitivity and 88.3% specificity at a cutoff of 94 pg/ml. There were no statistical differences in isoprostanes levels between AGA and SGA newborns in group II. The area under the ROC curve drawn to distinguish AGA and SGA newborns showed a sensitivity of 100% and a specificity of 72.3% at a cutoff of 94 pg/ml. The relative risk index indicated a 8.05 times higher risk of birth weight below the 3rd percentiles in group II than in group I. High isoprostanes concentrations can be detected in the amniotic fluid of FGR pregnancies and the assay of isoprostanes in amniotic fluid is a reliable assessment of fetal oxidative stress. Common use of this predictive marker in obstetrics will improve the ability of clinicians to identify those fetuses who will be born SGA or with a birth weight below the 25th percentile.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofFREE RADICAL BIOLOGY & MEDICINEen_US
dc.titleIsoprostanes in amniotic fluid: a predictive marker for fetal growth restriction in pregnancy.en_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.freeradbiomed.2005.02.017en_US
dc.identifier.pmid15890628en_US
dc.identifier.scopus2-s2.0-18944375054en_US
dc.identifier.isiWOS:000229398700015en_US
dc.relation.volume38en_US
dc.relation.issue11en_US
dc.description.firstpage1537en_US
dc.description.lastpage1541en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0002-4622-7054-
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