Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5046
DC FieldValueLanguage
dc.contributor.authorAnselmi, Ceciliaen_us
dc.contributor.authorBernardi, F.en_us
dc.contributor.authorCentini, Marisannaen_us
dc.contributor.authorGaggelli, Elenaen_us
dc.contributor.authorGaggelli, Nicolaen_us
dc.contributor.authorValensin, Danielaen_us
dc.contributor.authorValensin, Giannien_us
dc.date.accessioned2021-03-30T15:48:38Z-
dc.date.available2021-03-30T15:48:38Z-
dc.date.issued2005-
dc.identifier.issn0009-3084en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/5046-
dc.description35934en_US
dc.description.abstractFerulic acid (Fer), a natural anti-oxidant and chemo-protector, is able to suppress experimental carcinogenesis in the forestomach,lungs, skin, tongue and colon. Several Fer derivatives have been suggested as promising candidates for cancer prevention,being the biological activity related also to the capacity of partitioning between aqueous and lipid phases. In the present work,pulsed field gradient (PFG)NMRdiffusion measurement andNMRrelaxation rates have been adopted for investigating the interactionof three Fer derivatives (Fer-C11, Fer-C12 and Fer-C13) with human erythrocytes. Binding to the erythrocyte membranehas been shown for all derivatives, which displayed a similar interaction mode such that the aromatic moiety and the terminalpart of the alkyl chain were the most affected. Quantitative analysis of the diffusion coefficients was used to show that Fer-C12and Fer-C13 display higher affinity for the cell membrane when compared with Fer-C11. These findings agree with the higheranti-oxidant activity of the two derivatives.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofCHEMISTRY AND PHYSICS OF LIPIDSen_US
dc.subjectFerulic acid derivatives; PFG NMR; Relaxation; Erythrocytesen_US
dc.titleInteraction of ferulic acid derivatives with human erythrocytes monitored by pulse field gradient NMR diffusion and NMR relaxation studiesen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.chemphyslip.2004.12.005en_US
dc.identifier.pmid15784229en_US
dc.identifier.scopus2-s2.0-15244360955en_US
dc.identifier.isiWOS:000228527500003en_US
dc.relation.volume134en_US
dc.relation.issue2en_US
dc.description.firstpage109en_US
dc.description.lastpage117en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0003-3993-8234-
crisitem.author.orcid9810-
crisitem.author.orcid0000-0003-4187-3919-
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