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|Title:||Interaction of ferulic acid derivatives with human erythrocytes monitored by pulse field gradient NMR diffusion and NMR relaxation studies||Authors:||Anselmi, Cecilia
|Keywords:||Ferulic acid derivatives; PFG NMR; Relaxation; Erythrocytes||Issue Date:||2005||Project:||None||Journal:||CHEMISTRY AND PHYSICS OF LIPIDS||Abstract:||
Ferulic acid (Fer), a natural anti-oxidant and chemo-protector, is able to suppress experimental carcinogenesis in the forestomach,lungs, skin, tongue and colon. Several Fer derivatives have been suggested as promising candidates for cancer prevention,being the biological activity related also to the capacity of partitioning between aqueous and lipid phases. In the present work,pulsed field gradient (PFG)NMRdiffusion measurement andNMRrelaxation rates have been adopted for investigating the interactionof three Fer derivatives (Fer-C11, Fer-C12 and Fer-C13) with human erythrocytes. Binding to the erythrocyte membranehas been shown for all derivatives, which displayed a similar interaction mode such that the aromatic moiety and the terminalpart of the alkyl chain were the most affected. Quantitative analysis of the diffusion coefficients was used to show that Fer-C12and Fer-C13 display higher affinity for the cell membrane when compared with Fer-C11. These findings agree with the higheranti-oxidant activity of the two derivatives.
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