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|Title:||Design, Synthesis, and Binding Studies of New Potent Ligands of Cannabinoids Receptors||Authors:||Brizzi, Antonella
M. G., Cascio
|Issue Date:||2005||Project:||None||Journal:||JOURNAL OF MEDICINAL CHEMISTRY||Abstract:||
Despite their different chemical structures D9-tetrahydrocannabinol (THC) and anandamide (AEA) have common pharmacological properties. This study was aimed at finding new cannabinoid receptor ligands that overcome the instability of AEA and its analogues. To this end we planned the synthesis of a series of compounds which retained both a rigid structure, like that of plant cannabinoids, and a flexible portion similar to that of anandamide.
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