Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5036
DC FieldValueLanguage
dc.contributor.authorBiava, M.en_us
dc.contributor.authorPorretta, G. C.en_us
dc.contributor.authorCappelli, Andreaen_us
dc.contributor.authorVomero, S.en_us
dc.contributor.authorManetti, Fabrizioen_us
dc.contributor.authorBotta, Maurizioen_us
dc.contributor.authorSautebin, L.en_us
dc.contributor.authorRossi, A.en_us
dc.contributor.authorMakovec, F.en_us
dc.contributor.authorAnzini, Maurizioen_us
dc.date.accessioned2021-03-30T15:48:34Z-
dc.date.available2021-03-30T15:48:34Z-
dc.date.issued2005-
dc.identifier.issn0022-2623en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/5036-
dc.description35771en_US
dc.description.abstractA small set of substituted 1,5-diarylpyrrole-3-acetic and -glyoxylic acid derivatives have been synthesized, and their cyclooxygenase (COX-1 and COX-2) inhibiting properties have been evaluated. Some compounds proved to be highly selective COX-2 inhibitors, and their affinity data have been rationalized through docking simulations in terms of interactions with a crystallographic model of the COX-2 binding siteen_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofJOURNAL OF MEDICINAL CHEMISTRYen_US
dc.title1,5-Diarylpyrrole-3-acetic Acids and Esters as Novel Classes of Potent and Highly Selective Cyclooxygenase-2 Inhibitorsen_US
dc.typeArticleen_US
dc.identifier.doi10.1021/jm049121qen_US
dc.identifier.pmid15857149en_US
dc.identifier.scopus2-s2.0-20944435205en_US
dc.identifier.isiWOS:000228871700040en_US
dc.relation.volume48en_US
dc.relation.issue9en_US
dc.description.firstpage3428en_US
dc.description.lastpage3432en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0003-4140-3028-
crisitem.author.orcid0000-0002-9598-2339-
crisitem.author.orcid0000-0003-0456-6995-
crisitem.author.orcid0000-0002-7481-5566-
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