Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5036
Title: 1,5-Diarylpyrrole-3-acetic Acids and Esters as Novel Classes of Potent and Highly Selective Cyclooxygenase-2 Inhibitors
Authors: Biava, M.
Porretta, G. C.
Cappelli, Andrea 
Vomero, S.
Manetti, Fabrizio 
Botta, Maurizio 
Sautebin, L.
Rossi, A.
Makovec, F.
Anzini, Maurizio 
Issue Date: 2005
Project: None 
Journal: JOURNAL OF MEDICINAL CHEMISTRY
Abstract: 
A small set of substituted 1,5-diarylpyrrole-3-acetic and -glyoxylic acid derivatives have been synthesized, and their cyclooxygenase (COX-1 and COX-2) inhibiting properties have been evaluated. Some compounds proved to be highly selective COX-2 inhibitors, and their affinity data have been rationalized through docking simulations in terms of interactions with a crystallographic model of the COX-2 binding site
Description: 
35771
URI: http://hdl.handle.net/20.500.12779/5036
ISSN: 0022-2623
DOI: 10.1021/jm049121q
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