Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5032
Title: The effect of amidic moieties on the polysaccharides: evaluation of the physico-chemical and biological properties of amidic carboxymethylcellulose (CMCA) in the form of linear polymer and hydrogel
Authors: Barbucci, Rolando
Leone, Gemma 
M., Monici
D., Pantalone
M., Fini
R., Giardino
Issue Date: 2005
Project: None 
Journal: JOURNAL OF MATERIALS CHEMISTRY
Abstract: 
A new derivative of carboxymethylcellulose was synthesised by converting some of the carboxylic groups into amidic moieties (CMCA). The synthetic procedure allowed for a good control of the degree of substitution. The new polysaccharide was characterised in terms of physico-chemical properties and biocompatibility. It was also used for the realisation of a hydrogel, and its physicochemical behaviour, such as water uptake and rheological parameters, were evaluated. The new CMCA hydrogel showed physico-chemical properties closer to those of Hyaluronan (Hyal) rather than native carboxymethylcellulose (CMC). Hydrogel cytotoxicity and biological activity were then comparatively investigated on osteoblast-like cells, taking into consideration the possible application of the hydrogel as a cell scaffold in orthopaedic tissue engineering. Finally, the effectiveness of cellular scaffolds for b-pancreatic islet cells was also studied.
Description: 
36342
URI: http://hdl.handle.net/20.500.12779/5032
ISSN: 0959-9428
DOI: 10.1039/b503399c
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