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Title: Potential Antitumor Agents. 34. (1) Synthesis and Antitumor Activity of Guanylhydrazones from Imidazo[2,1-b]thiazoles and from Diimidazo[1,2-a:1,2-c]pyrimidine
Authors: Aldo, Andreani
Massimiliano, Granaiola
Alberto, Leoni
Alessandra, Locatelli
Rita, Morigi
Mirella, Rambaldi
Giorgi, Gianluca 
Vida, Garaliene
Issue Date: 2004
Project: None 
We report the synthesis of new guanylhydrazones from imidazo[2,1-b]thiazoles and of a bis-guanylhydrazone from diimidazo[1,2-a:1,2-c]pyrimidine. The compounds were tested as potential antitumor agents at the National Cancer Institute. Two derivatives are now under review by BEC: one of these was also subjected to a test for positive inotropic activity in view of a possible coanthracyclinic activity. Tyrosine kinase receptors may be involved as molecular targets in the mechanism of action of the guanylhydrazones described.
ISSN: 0250-7005
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