Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4958
Title: Antimycobacterial compounds. New pyrrole derivatives of BM212
Authors: Biava, M.
Porretta, G. C.
Deidda, D.
Pompei, R.
Tafi, Andrea 
Manetti, Fabrizio 
Keywords: Antimycobacterial activity; Pharmacophore model; Pyrrole derivatives; Thiomorpholine substituent
Issue Date: 2004
Project: None 
Journal: BIOORGANIC & MEDICINAL CHEMISTRY
Abstract: 
We have identified BM212 as a lead compound among a series of pyrrole derivatives with good in vitro activity against mycobacteria and candidae. First studies led us to synthesize some pyrrole compounds in which the thiomorpholine fragment was present. Some compounds revealed very active and these findings prompted us to prepare new pyrrole derivatives 2-15 in the hope of increasing the activity. The microbiological data showed interesting in vitro activity against Mycobacterium tuberculosis and atypical mycobacteria.
Description: 
25420
URI: http://hdl.handle.net/20.500.12779/4958
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2003.12.037
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