Please use this identifier to cite or link to this item:
|Title:||Antimycobacterial compounds. New pyrrole derivatives of BM212||Authors:||Biava, M.
Porretta, G. C.
|Keywords:||Antimycobacterial activity; Pharmacophore model; Pyrrole derivatives; Thiomorpholine substituent||Issue Date:||2004||Project:||None||Journal:||BIOORGANIC & MEDICINAL CHEMISTRY||Abstract:||
We have identified BM212 as a lead compound among a series of pyrrole derivatives with good in vitro activity against mycobacteria and candidae. First studies led us to synthesize some pyrrole compounds in which the thiomorpholine fragment was present. Some compounds revealed very active and these findings prompted us to prepare new pyrrole derivatives 2-15 in the hope of increasing the activity. The microbiological data showed interesting in vitro activity against Mycobacterium tuberculosis and atypical mycobacteria.
|Appears in Collections:||Publications|
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.