Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4950
Title: Prediction of quaternary assembly of SARS coronavirus peplomer.
Authors: Bernini, A
Spiga, Ottavia 
Ciutti, A
Chiellini, S
Bracci, Luisa
Yan, X
Zheng, B
Huang, J
He, Ml
Song, Hd
Hao, P
Zhao, G
Niccolai, Neri 
Issue Date: 2004
Project: None 
Journal: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Abstract: 
The tertiary structures of the S1 and S2 domains of the spike protein of the coronavirus which is responsible of the severe acute respiratory syndrome (SARS) have been recently predicted. Here a molecular assembly of SARS coronavirus peplomer which accounts for the available functional data is suggested. The interaction between S1 and S2 appears to be stabilised by a large hydrophobic network of aromatic side chains present in both domains. This feature results to be common to all coronaviruses, suggesting potential targeting for drugs preventing coronavirus-related infections.
Description: 
36836
URI: http://hdl.handle.net/20.500.12779/4950
ISSN: 0006-291X
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