Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4929
DC FieldValueLanguage
dc.contributor.authorSchenone, S.en_us
dc.contributor.authorBruno, O.en_us
dc.contributor.authorBondavalli, F.en_us
dc.contributor.authorRanise, A.en_us
dc.contributor.authorMosti, L.en_us
dc.contributor.authorMenozzi, G.en_us
dc.contributor.authorFossa, P.en_us
dc.contributor.authorDonnini, Sandraen_us
dc.contributor.authorSantoro, A.en_us
dc.contributor.authorZiche, Marinaen_us
dc.contributor.authorManetti, Fabrizioen_us
dc.contributor.authorBotta, Maurizioen_us
dc.date.accessioned2021-03-30T15:45:38Z-
dc.date.available2021-03-30T15:45:38Z-
dc.date.issued2004-
dc.identifier.issn0223-5234en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/4929-
dc.description35763en_US
dc.description.abstractSynthesis and biological evaluation of a new class of 1-aryl-4-amino-1H- pyrazolo[3,4-d]pyrimidine derivatives are reported. A preliminary cellular assay system using the tumor cell line A431 responding to epidermal growth factor (EGF) for its growth, shows that the new compounds are potent inhibitors of cell growth. The inhibition of tumor cell proliferation is not associated with blockage of EGF receptor (EGFR), but substantially due to the interference with the signalling pathway at the level of Src tyrosine kinase and at the level of the downstream effector signal mitogen activated protein kinases (MAPKs), ERK1-2.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofEUROPEAN JOURNAL OF MEDICINAL CHEMISTRYen_US
dc.subjectA431 cells; Antiproliferative activity; Pyrazolo-pyrimidine; Tyrosine kinaseen_US
dc.titleAntiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line.en_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.ejmech.2004.07.010en_US
dc.identifier.pmid15501543en_US
dc.identifier.scopus2-s2.0-6344226300en_US
dc.identifier.isiWOS:000225171200005en_US
dc.relation.volume39en_US
dc.relation.issue11en_US
dc.description.firstpage939en_US
dc.description.lastpage946en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0002-9598-2339-
crisitem.author.orcid0000-0003-0456-6995-
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