Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4921
Title: Pyrazolo[3,4-d]pyrimidines Endowed with Antiproliferative Activity on Ductal Infiltrating Carcinoma Cells.
Authors: Carraro, Fabio
Pucci, Annalisa
Naldini, Antonella
Schenone, S.
Bruno, O.
Ranise, A.
Bondavalli, B.
Brullo, C.
Fossa, P.
Menozzi, G.
Mosti, L.
Manetti, Fabrizio 
Botta, Maurizio 
Issue Date: 2004
Project: None 
Journal: JOURNAL OF MEDICINAL CHEMISTRY
Abstract: 
Novel 1,4,6-trisubstituted pyrazolo[3,4-d]pyrimidines are reported with preliminary in vitro activity data indicating that several of them are potent inhibitors (better than the reference compound) of Src phosphorylation of the breast cancer cells 8701-BC, known to overexpress Src. The ability of such compounds to significantly reduce 8701-BC cell proliferation suggests that this scaffold could be a promising lead for the development of antitumoral agents able to block Src phosphorylation of breast cancer cells.
Description: 
37636
URI: http://hdl.handle.net/20.500.12779/4921
ISSN: 0022-2623
DOI: 10.1021/jm034257u
Appears in Collections:Publications

Show full item record

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.