Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4919
Title: Microwave-assisted synthesis and biological evaluation of novel uracil derivatives inhibiting human thymidine phosphorylase
Authors: Corelli, Federico 
Botta, Maurizio 
Lossani, Andrea
Pasquini, Serena
Spadari, Silvio
Focher, Federico
Issue Date: 2004
Project: None 
Journal: IL FARMACO
Abstract: 
New 5-chloro-6-substituted-uracil derivs. have been prepd. by microwave assisted-synthesis and tested in vitro as thymidine phosphorylase inhibitors. One of these compds. showed potent inhibitory activity, with an IC50 value in the submicromolar range. The biol. activity of the new compds. is discussed in terms of structure-activity relationship.
Description: 
44466
URI: http://hdl.handle.net/20.500.12779/4919
ISSN: 0014-827X
DOI: 10.1016/j.farmac.2004.08.007
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