Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4918
Title: New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation
Authors: Schenone, S
Bruno, O
Ranise, A
Bondavalli, F
Brullo, C
Fossa, P
Mosti, L
Menozzi, G
Carraro, Fabio
Naldini, Antonella
Bernini, C
Manetti, Fabrizio 
Botta, Maurizio 
Issue Date: 2004
Project: None 
Journal: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Abstract: 
New 4-aminopyrazolo[3,4-d]pyrimidines bearing various substituents at the position 1 and 6, were synthesized. The new compounds showed antiproliferative activity toward A431 cells, were found to be inhibitors of Src phosphorylation, and induced apoptotic cell death. In particular, 2h was a better inhibitor of Src phosphorylation than the reference compound PP2.
Description: 
36330
URI: http://hdl.handle.net/20.500.12779/4918
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2004.03.013
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