Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4915
Title: Computational Comparison of Microtubule-Stabilising Agents Laulimalide and Peloruside with Taxol and Colchicine
Authors: Pineda, O.
Farras, J.
Maccari, L.
Manetti, Fabrizio 
Botta, Maurizio 
Vilarrasa, J.
Keywords: Anti-cancer drugs; Docking; Laulimalide; Modelling; Peloruside
Issue Date: 2004
Project: None 
Journal: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Abstract: 
Microtubule-stabilising agents laulimalide and peloruside have been compared with tubulin-interacting drugs paclitaxel and colchicine by different computational approaches. Docking and QSAR-based programs point to a favourable interaction with the β tubulin paclitaxel binding site, although an additional, preferred binding site has been found at the α subunit of tubulin. All together provides a plausible rationalisation of the singular binding features of these microtubule stabilisers and paves the way for future structural studies.
Description: 
35234
URI: http://hdl.handle.net/20.500.12779/4915
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2004.07.053
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