Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4898
Title: Boronphenylalanine Insertion in Cationic Liposomes for Boron Neutron Capture Therapy
Authors: Martini, S
Ristori, S
Pucci, A
Bonechi, Claudia 
Becciolini, A
Martini, G
Rossi, Claudio 
Issue Date: 2004
Project: None 
Journal: BIOPHYSICAL CHEMISTRY
Abstract: 
Cationic liposomes are widely used as carriers of biomolecules specifically targeted to the cell nucleus. p-Boronphenylalanine (BPA) is powerful anti-tumor agent for Boron Neutron Capture Therapy (BNCT). In this paper, 1H and 13C NMR was used to study the insertion of BPA in mixed liposomes, made up by the positively charged 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) and the zwitterionic 1,2dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE). The boronated drug was distributed between the water phase and the liposomes. The location site of BPA into the lipid bilayer was investigated and the boron-substituted aromatic ring was found inserted in the hydrophobic region, whereas the amino acidic group was oriented towards the aqueous environment. Further information was given by proton spin-lattice relaxation rates.
Description: 
37192
URI: http://hdl.handle.net/20.500.12779/4898
ISSN: 0301-4622
Appears in Collections:Publications

Show full item record

Page view(s)

20
Last Week
8
Last month
8
checked on May 12, 2021

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.