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|Title:||Microwave assisted Paal-Knorr reaction. A rapid approach to polysubstituted furans and pyrroles||Authors:||G., Minetto
|Issue Date:||2004||Project:||None||Journal:||ORGANIC LETTERS||Abstract:||
An array of tetrasubstituted pyrroles (and trisubstituted furans) was obtained using a simple three-step procedure. Functional homologation of a -ketoester with an aldehyde followed by oxidation gave a series of differently substituted 1,4-dicarbonyl compounds that can be rapidly cyclized with the Paal−Knorr procedure carried out under microwave irradiation.
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