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|Title:||An innovative approach to the design of plastic antibodies: molecular imprinting via a non polari transition state analogue.||Authors:||Busi, Elena
|Keywords:||Plastic antibody; Transition state; Imprinted polymer; Acrylic resin; Transition state analogue||Issue Date:||2004||Project:||None||Journal:||JOURNAL OF MOLECULAR CATALYSIS. A: CHEMICAL||Abstract:||
An acrylic resin imprinted with a transition state analogue which possesses a dominant non-polar structure was synthesized. As a modelfor this study the Diels–Alder reaction was chosen since, it is well-known and possesses a stable and synthetically achievable transition stateanalogue. It is shown that the plastic antibody synthesized in this study catalyzes the Diels–Alder reaction with an efficiency comparable tothat of a recently developed monoclonal catalytic antibody. In fact the Lineweaver–Burk Vmax observed for the two catalysts appears to beof the same order of magnitude. We argue that plastic antibodies can be successfully used to catalyze reactions with a transition state of lowpolarity. Moreover, they appear to represent a more flexible catalyst when varied reaction conditions and solvent environments are needed.
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