Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4891
Title: An innovative approach to the design of plastic antibodies: molecular imprinting via a non polari transition state analogue.
Authors: Busi, Elena 
Basosi, Riccardo 
Ponticelli, Fabio
Olivucci, Massimo 
Keywords: Plastic antibody; Transition state; Imprinted polymer; Acrylic resin; Transition state analogue
Issue Date: 2004
Project: None 
Journal: JOURNAL OF MOLECULAR CATALYSIS. A: CHEMICAL
Abstract: 
An acrylic resin imprinted with a transition state analogue which possesses a dominant non-polar structure was synthesized. As a modelfor this study the Diels–Alder reaction was chosen since, it is well-known and possesses a stable and synthetically achievable transition stateanalogue. It is shown that the plastic antibody synthesized in this study catalyzes the Diels–Alder reaction with an efficiency comparable tothat of a recently developed monoclonal catalytic antibody. In fact the Lineweaver–Burk Vmax observed for the two catalysts appears to beof the same order of magnitude. We argue that plastic antibodies can be successfully used to catalyze reactions with a transition state of lowpolarity. Moreover, they appear to represent a more flexible catalyst when varied reaction conditions and solvent environments are needed.
Description: 
38036
URI: http://hdl.handle.net/20.500.12779/4891
ISSN: 1381-1169
DOI: 10.1016/j.molcata.2004.03.044
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