Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4887
Title: Synthesis of 1-(2-chloro-2-phenylethyl)-6-methylthio-1H-pyrazolo[3,4-d]pyrimidines 4-Amino Substituted and Their Biological Evaluation.
Authors: Schenone, S.
Bruno, O.
Bondavalli, F.
Ranise, A.
Mosti, L.
Menozzi, G.
Fossa, P.
Manetti, Fabrizio 
Morbidelli, Lucia
Trincavelli, L.
Martini, C.
Lucacchini, A.
Issue Date: 2004
Project: None 
Journal: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Abstract: 
A new series of 4-amino-6-methylthio-1H-pyrazolo[3,4-d]pyrimidines (2a-m) bearing the 2-chloro-2-phenylethyl chain at the N1 position, has been synthesized. The affinity of these compounds for A1 adenosine receptor (A1AR) was measured. The compounds showed poor affinity. A more interesting result was obtained by 2a, 2d, 2g, which demonstrated inhibitory activity on cell proliferation of the A-431 cell line stimulated by epithelial growth factor (EGF) and on EGF receptor tyrosine kinase (EGFR-TK) phosphorylation.
Description: 
38591
URI: http://hdl.handle.net/20.500.12779/4887
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2003.11.007
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