Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4885
Title: Formation of defined microporous 3D-structures starting from cross-linked hydrogels
Authors: Barbucci, Rolando
Leone, Gemma 
Keywords: polysaccharide; hydrogel; porous morphology; water up-take; FT-IR analysis
Issue Date: 2004
Project: None 
Journal: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART B, APPLIED BIOMATERIALS.
Abstract: 
A new and simple technique was developed to obtain polysaccharide (hyaluronane, alginate and carboxymethylcellulose) -based hydrogels with a defined porous morphology. The technique consists of stratifying a cross-linked hydrogel on a filter with known pore diameter. CO2 bubbles, produced by the addition of HCl to a porogen salt NaHCO3, are forced to pass through the filter, and they induce the hydrogel to assume a porous morphology. The presence and distribution of pores was confirmed by scanning-electron microscopy (SEM). A strict correspondence was found between the porosity of the filter and the pore diameter in the hydrogels. Water uptake measurements showed a decreased amount of water taken up by the porous hydrogels compared with the native hydrogels, due to a compacting of the material. An explanation of the porous material properties of Hyal hydrogel was given on the basis of FTIR spectra.I
Description: 
36322
URI: http://hdl.handle.net/20.500.12779/4885
ISSN: 1552-4973
DOI: 10.1002/jbm.b.20005
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