Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4833
DC FieldValueLanguage
dc.contributor.authorGaggelli, Elenaen_us
dc.contributor.authorN., D'Amelioen_us
dc.contributor.authorValensin, Danielaen_us
dc.contributor.authorValensin, Giannien_us
dc.date.accessioned2021-03-30T15:45:01Z-
dc.date.available2021-03-30T15:45:01Z-
dc.date.issued2003-
dc.identifier.issn0749-1581en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/4833-
dc.description36820en_US
dc.description.abstractWe review recent developments in the studies of Cu(II) complexes with histidine-containing peptides in solution by NMR. An overview of the theoretical background of the effects of the paramagnetic metal on the NMR properties (relaxation and shift) of nearby nuclei is given. Particular attention is paid to the effect of exchange rates between free and metal-bound forms of the ligand on detection of paramagnetic relaxation rates. General methods are underlined to determine the structure of the complexes (and thus the donor set to the metal) and to distinguish between the binding of copper(II) to either N-1 or N-3 of the imidazole ring of histidine. Examples are reported dealing with fragments of the amyloid precursor protein (a protein related to Alzheimer's disease) and of the prion protein (related to Creutzfeldt–Jakob disease) in which the binding of copper may be relevant for subsequent redox activities, protein aggregation or metal-catalyzed protein damage.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofMAGNETIC RESONANCE IN CHEMISTRYen_US
dc.title1H-NMR Studies of Copper Binding by Histidine Containing Peptidesen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/mrc.1250en_US
dc.identifier.scopus2-s2.0-0242330657en_US
dc.identifier.isiWOS:000185662200018en_US
dc.relation.volume41en_US
dc.description.firstpage877en_US
dc.description.lastpage883en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid9810-
crisitem.author.orcid0000-0003-4187-3919-
Appears in Collections:Publications
Show simple item record

Page view(s)

2
Last Week
0
Last month
0
checked on Jun 19, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.