Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4829
DC FieldValueLanguage
dc.contributor.authorBova, Sen_us
dc.contributor.authorCavalli, Men_us
dc.contributor.authorCima, Len_us
dc.contributor.authorLuciani, Sen_us
dc.contributor.authorSaponara, Simonaen_us
dc.contributor.authorSgaragli, GIAN PIETROen_us
dc.contributor.authorCargnelli, Gen_us
dc.contributor.authorFusi, Fabioen_us
dc.date.accessioned2021-03-30T15:44:59Z-
dc.date.available2021-03-30T15:44:59Z-
dc.date.issued2003-
dc.identifier.issn0014-2999en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/4829-
dc.description37799en_US
dc.description.abstractWe have investigated the effects of the rat-specific vasoconstrictor agent norbormide on the mechanical and electrophysiological properties of rat non-vascular smooth muscles. Norbormide (50 microM) did not affect the resting tone of urinary bladder, tracheal, and duodenal rings. In all tissues, KCl-induced concentration-response curves were shifted downward by norbormide (5 and 50 microM). In urinary bladder and tracheal rings, norbormide inhibited contractile responses to carbachol only at the higher concentration (50 microM). In single gastric fundus myocytes, 50 microM norbormide inhibited L-type Ca(2+) current (I(Ca(L))) by about 60%, neither affecting both activation and inactivation rates of the current nor the current-voltage curve along the voltage axis. Our results indicate that rat non-vascular smooth muscles are relaxed by norbormide with a mechanism likely involving a reduction of Ca(2+) entry through L-type Ca(2+) channels.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofEUROPEAN JOURNAL OF PHARMACOLOGYen_US
dc.titleRelaxant and Ca2+ channel blocking properties of norbormide on rat non-vascular smooth muscles.en_US
dc.typeArticleen_US
dc.identifier.pmid12798957en_US
dc.identifier.scopus2-s2.0-0038545278en_US
dc.identifier.isiWOS:000183642600009en_US
dc.relation.volume470en_US
dc.relation.issue3en_US
dc.description.firstpage185en_US
dc.description.lastpage191en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0002-5737-8309-
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