Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4829
Title: Relaxant and Ca2+ channel blocking properties of norbormide on rat non-vascular smooth muscles.
Authors: Bova, S
Cavalli, M
Cima, L
Luciani, S
Saponara, Simona
Sgaragli, GIAN PIETRO
Cargnelli, G
Fusi, Fabio 
Issue Date: 2003
Project: None 
Journal: EUROPEAN JOURNAL OF PHARMACOLOGY
Abstract: 
We have investigated the effects of the rat-specific vasoconstrictor agent norbormide on the mechanical and electrophysiological properties of rat non-vascular smooth muscles. Norbormide (50 microM) did not affect the resting tone of urinary bladder, tracheal, and duodenal rings. In all tissues, KCl-induced concentration-response curves were shifted downward by norbormide (5 and 50 microM). In urinary bladder and tracheal rings, norbormide inhibited contractile responses to carbachol only at the higher concentration (50 microM). In single gastric fundus myocytes, 50 microM norbormide inhibited L-type Ca(2+) current (I(Ca(L))) by about 60%, neither affecting both activation and inactivation rates of the current nor the current-voltage curve along the voltage axis. Our results indicate that rat non-vascular smooth muscles are relaxed by norbormide with a mechanism likely involving a reduction of Ca(2+) entry through L-type Ca(2+) channels.
Description: 
37799
URI: http://hdl.handle.net/20.500.12779/4829
ISSN: 0014-2999
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