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Title: Synthesis and conformational studies of 3’-(2’-aminoborane-2’-deoxyuridyl)-5’-thymidilyl hydrogen phospate to be used in the construction of oligonucleotide sequences
Authors: Stasi, L. P.
Mugnaini, Claudia 
Alcaro, S.
Corelli, Federico 
Botta, Maurizio 
Issue Date: 2003
Project: None 
The synthesis of the boronated dinucleotide (2) starting from commercially available building blocks was accomplished according to the phosphoramidite approach. The dimer, which can be used in the construction of oligonucleotide sequences, is itself interesting for its potential applications in Boron Neutron Capture Therapy and as a possible inhibitor of HIV-1 integrase. Computational studies were also performed showing its preferential C3'-endo (RNA-like) conformation
ISSN: 0385-5414
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