Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4808
DC FieldValueLanguage
dc.contributor.authorL., Maccarien_us
dc.contributor.authorCorelli, Federicoen_us
dc.contributor.authorManetti, Fabrizioen_us
dc.contributor.authorBotta, Maurizioen_us
dc.date.accessioned2021-03-30T15:44:50Z-
dc.date.available2021-03-30T15:44:50Z-
dc.date.issued2003-
dc.identifier.issn0014-827Xen_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/4808-
dc.description24332en_US
dc.description.abstractThe antimitotic agent paclitaxel continues to play an important role in the cancer chemotherapy. However, its inefficacy on certain resistant cells and toxic side effects have led to the search of new taxanes with improved biological activity. By means of a pseudoreceptor modeling approach, we have developed a binding site model for a series of taxanes. It is the first 3D QSAR model derived from the experimentally determined tubulin structure obtained by electron crystallography studies. The model is able to correlate quantitatively the structural properties of the studied compounds with their biological data.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofIL FARMACOen_US
dc.subject3D QSAR; Pseudoreceptor modeling; Taxanes; Tubulinen_US
dc.title3D QSAR STUDIES OF THE INTERACTION BETWEEN BETA-TUBULIN AND MICROTUBULE STABILIZING ANTIMITOTIC AGENTS (MSAA). A PSEUDORECEPTOR MODEL FOR TAXANES BASED ON THE EXPERIMENTAL STRUCTURE OF TUBULIN.en_US
dc.typeArticleen_US
dc.identifier.doi10.1016/S0014-827X(03)00099-5en_US
dc.identifier.pmid13679158en_US
dc.identifier.scopus2-s2.0-0141455184en_US
dc.relation.volume58en_US
dc.relation.issue9en_US
dc.description.firstpage659en_US
dc.description.lastpage668en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0002-5750-4504-
crisitem.author.orcid0000-0002-9598-2339-
crisitem.author.orcid0000-0003-0456-6995-
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