Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4808
Title: 3D QSAR STUDIES OF THE INTERACTION BETWEEN BETA-TUBULIN AND MICROTUBULE STABILIZING ANTIMITOTIC AGENTS (MSAA). A PSEUDORECEPTOR MODEL FOR TAXANES BASED ON THE EXPERIMENTAL STRUCTURE OF TUBULIN.
Authors: L., Maccari
Corelli, Federico 
Manetti, Fabrizio 
Botta, Maurizio 
Keywords: 3D QSAR; Pseudoreceptor modeling; Taxanes; Tubulin
Issue Date: 2003
Project: None 
Journal: IL FARMACO
Abstract: 
The antimitotic agent paclitaxel continues to play an important role in the cancer chemotherapy. However, its inefficacy on certain resistant cells and toxic side effects have led to the search of new taxanes with improved biological activity. By means of a pseudoreceptor modeling approach, we have developed a binding site model for a series of taxanes. It is the first 3D QSAR model derived from the experimentally determined tubulin structure obtained by electron crystallography studies. The model is able to correlate quantitatively the structural properties of the studied compounds with their biological data.
Description: 
24332
URI: http://hdl.handle.net/20.500.12779/4808
ISSN: 0014-827X
DOI: 10.1016/S0014-827X(03)00099-5
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