Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4801
DC FieldValueLanguage
dc.contributor.authorBarbucci, Rolandoen_us
dc.contributor.authorM., Consumien_us
dc.contributor.authorLamponi, Stefaniaen_us
dc.contributor.authorLeone, Gemmaen_us
dc.date.accessioned2021-03-30T15:44:47Z-
dc.date.available2021-03-30T15:44:47Z-
dc.date.issued2003-
dc.identifier.issn1022-1360en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/4801-
dc.description35157en_US
dc.description.abstractPolysaccharides based hydrogels show several peculiar properties which can be so reassumed: • Capability to absorb a great amount of water once immersed in biological fluids, assuming, consequently, a structure similar to extracellular matrix or biological tissue • Tissotropic property, i.e. possibility to be injected through a needle without lose of their rheological properties. These fundamental properties make them ideal materials for several biomedical applications, such as cellular scaffold, coatings for biomedical disposals, treatments for different diseases, controlled release of drugs, etc. Hyaluronane, Carboxymethyl cellulose and Alginic acid based 50% hydrogels (i.e. 50% of the carboxylate groups present in the macromolecule chain were involved in the cross-linking reaction) are synthesised. Their effectiveness in promoting cells adhesion and proliferation was verified. Furthermore the possibility of injecting and sterilising hydrogels permitted to test the effect of Hyal 50% in the osteoarthritis therapy. It was found that the in vivo effect of Hyal 50% in the treatment of surgically created chondral defect in the rabbit knee was positive. These materials can be both chemically and morphologically modified. In fact, the insertion of sulphate groups increase their hemocompatibility as demonstred by the increase of TT (time necessary to turn the fibrinogen to thrombin). Furthermore microporous hydrogels were obtained and tested as drug controlled release systems.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofMACROMOLECULAR SYMPOSIAen_US
dc.subjectadhesion; hydrogels; mechanical properties; microporosity; polysaccharidesen_US
dc.titlePolysaccharides based hydrogels for biological applicationsen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/masy.200351405en_US
dc.identifier.scopus2-s2.0-0346732132en_US
dc.identifier.isiWOS:000187455200006en_US
dc.relation.volume204en_US
dc.description.firstpage37en_US
dc.description.lastpage58en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0002-2788-8797-
crisitem.author.orcid0000-0002-0820-6068-
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