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|Title:||Importance of the Thiomorpholine Introduction in New Pyrrole Derivatives as Antimycobacterial Agents Analogues of BM 212||Authors:||Manetti, Fabrizio
G. C., Porretta
|Issue Date:||2003||Project:||None||Journal:||BIOORGANIC & MEDICINAL CHEMISTRY||Abstract:||
During the course of our investigations in the field of azole antimicrobial agents, we have identified BM 212, a pyrrole derivative with good in vitro activity against mycobacteria and candidae. These findings prompted us to prepare new pyrrole derivatives 1-10 in the hope of increasing the activity. The microbiological data showed interesting in vitro activity against Mycobacterium tuberculosis and atypical mycobacteria.
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