Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4697
DC FieldValueLanguage
dc.contributor.authorSpiga, Ottaviaen_us
dc.contributor.authorBernini, Andreaen_us
dc.contributor.authorScarselli, M.en_us
dc.contributor.authorCiutti, A.en_us
dc.contributor.authorBracci, Luisaen_us
dc.contributor.authorLozzi, Luisaen_us
dc.contributor.authorLelli, B.en_us
dc.contributor.authorDI MARO, D.en_us
dc.contributor.authorCalamandrei, D.en_us
dc.contributor.authorNiccolai, Nerien_us
dc.date.accessioned2021-03-30T15:44:01Z-
dc.date.available2021-03-30T15:44:01Z-
dc.date.issued2002-
dc.identifier.issn0014-5793en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/4697-
dc.description35473en_US
dc.description.abstractThe structural features of the complexes that alpha-bungarotoxin forms with three different synthetic peptides, mimotopes of the nicotinic acetylcholine receptor binding site, have been compared to the corresponding nuclear magnetic resonance (NMR) and surface plasmon resonance (SPR) data. For the considered peptides, the observed different affinities towards the toxin could not be accounted simply by static structural considerations. A combined analysis of the SPR- and NMR-derived dynamic parameters shows new correlations between complex formation and dissociation and the overall pattern of intramolecular and intermolecular nuclear Overhauser effects. These features could be crucial for a rational design of protein ligands.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofFEBS LETTERSen_US
dc.titlePeptide-protein interactions studied by surface plasmon and nuclear magnetic resonances.en_US
dc.typeArticleen_US
dc.identifier.doi10.1016/S0014-5793(01)03274-4en_US
dc.identifier.pmid11821044en_US
dc.identifier.scopus2-s2.0-18244377694en_US
dc.identifier.isiWOS:000173628000007en_US
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0014579301032744en_US
dc.relation.volume511en_US
dc.description.firstpage33en_US
dc.description.lastpage35en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0002-0263-7107-
crisitem.author.orcid0000-0002-7528-2749-
crisitem.author.orcid0000-0002-6919-6908-
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