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|Title:||New derivatives of toluidine: synthesis, antitubercular activity and pharmacophore hypothesis||Authors:||Biava, M.
Porretta, G. C.
|Issue Date:||2002||Project:||None||Journal:||MEDICINAL CHEMISTRY RESEARCH||Abstract:||
New toluidine derivatives are described. Some of them showed interesting activity against Mycobacteria. They led to an optimization of the pharmacophore model previously described by us. The best-fitted conformer of one of the most active compounds (6a) shows all the chemical groups matched to the chemical features of the model.
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