Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4676
Title: A new and efficient synthesis of substituted 6-[(2'-dialkylamino)ethyl] pyrimidine and 4-N,N-dialkyl-6-vinyl-cytosine derivatives and evaluation of their anti-rubella activity.
Authors: Saladino, Raffaele
Ciambecchini, Umberto
Maga, Giovanni
Mastromarino, Paola
Conti, Cinzia
Botta, Maurizio 
Issue Date: 2002
Project: None 
Journal: BIOORGANIC & MEDICINAL CHEMISTRY
Abstract: 
New 6-[(2'-dialkylamino)ethyl]-4(3H)-pyrimidinones were prepared by a multistep procedure starting from acetone dicarboxylic acid diethyl ester and urea derivatives. These compounds were used as starting materials to obtain 4-N,N-dialkyl-6-vinyl-pyrimidine derivatives by an unprecedented tandem C-6 side chain Hofmann-like elimination/C-4 pyrimidinone substitution. Among the new derivatives obtained, various compounds show anti-Rubella activity. The inhibition of HIV-1 Reverse Transcriptases (RT), from both wild type and modified viruses, is also reported.
Description: 
22383
URI: http://hdl.handle.net/20.500.12779/4676
ISSN: 0968-0896
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