Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4669
DC FieldValueLanguage
dc.contributor.authorManetti, Fabrizioen_us
dc.contributor.authorCorelli, Federicoen_us
dc.contributor.authorStrappaghetti, Gen_us
dc.contributor.authorBotta, Maurizioen_us
dc.date.accessioned2021-03-30T15:43:49Z-
dc.date.available2021-03-30T15:43:49Z-
dc.date.issued2002-
dc.identifier.issn0929-8673en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/4669-
dc.description36442en_US
dc.description.abstractIn the last years, α1 adrenoceptors (α1-AR) have been the subject of intense research, in part because receptor-binding studies and molecular biology have opened up new aspects of understanding but also because of the potential to find new drugs possibly acting toward pathophysiological processes where α1-AR are involved, such as benign prostatic hyperplasia (BPH) or hypertension. At present, arylpiperazines represent one of the most studied classes of molecules with affinity at α1-AR. In fact, a large amount of work has been done and reported, describing synthetic procedures, biological evaluation at both α1-AR and the corresponding subtypes, and structure-activity relationships (SARs). In this paper, a review based on a literature survey aimed at focusing on the structural properties that a compound should possess to show affinity toward α1-AR is presented. Moreover, the identification and optimization of the structural features of a hit compound derived from a pharmacophore-based database search, leading to a new class of arylpiperazinylalkyl pyridazinone derivatives with α1-AR affinity is reported.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofCURRENT MEDICINAL CHEMISTRYen_US
dc.subjectα1-adrenoceptors; Arylpiperazines; Database search; Pharmacophore model; Structure-affinity relationshipsen_US
dc.titleArylpiperazines with high affinity toward a1-adrenergic receptorsen_US
dc.typeArticleen_US
dc.identifier.pmid12052168en_US
dc.identifier.scopus2-s2.0-0036287769en_US
dc.identifier.isiWOS:000176238400004en_US
dc.relation.volume9en_US
dc.relation.issue13en_US
dc.description.firstpage1303en_US
dc.description.lastpage1321en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0002-9598-2339-
crisitem.author.orcid0000-0002-5750-4504-
crisitem.author.orcid0000-0003-0456-6995-
Appears in Collections:Publications
Show simple item record

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.