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Title: Role of apically bound water molecule on aliphatic-aliphatic side-chain interactions in bis [N,N-dimethyl-L-α-isoleucinato]copper(II) studied by EPR spectroscopy
N., Paulic
Basosi, Riccardo 
Pogni, Rebecca 
Keywords: EPR spectroscopy; copper(II) complexes; amino acids; N; N-dimethyl-L-α-isoleucine
Issue Date: 2002
Project: None 
In order to show the importance of conformation of the amino acid side-chains on water binding or water release to the copper(II)in complexes with long aliphatic side-chains, the temperature dependence of Brownian motion of the bis[N,N-dimethyl-L-aalaninato]copper(II) complex compared with the bis[N,N-dimethyl-L-a-isoleucinato]copper(II) complex dissolved in deuteratedmethanol is analyzed. The hypothesis is that binding or release of the water molecule from copper(II) in the complex with N,Ndimethyl-L-a-isoleucine may be related to the conformation change of the amino acid side-chains. In the case of bis[N,N-dimethyl-L-a-alaninato]copper(II) the conformation change of the amino acid side-chains (/CH3) is not possible. If the copper(II) complexretains one conformation in the examined temperature interval, the reorientation correlation time t2, describing the Brownianmotion of the complex will be a linear function of h/T, as is obtained for bis[N,N-dimethyl-L-a-alaninato]copper(II). In the wholetemperature interval measured (276/332 K), the electron paramagnetic resonance (EPR) spectra are fitted well with characteristicparameters for the complex with bound water. For bis[N,N-dimethyl-L-a-isoleucinato]copper(II) more complex temperaturedependence of t2 on h/T is obtained. Above 300 K, the EPR spectra could not be fitted with the parameters of the complex withbound water, but are fitted well with the parameters characteristic for a copper(II) complex that does not contain an apical watermolecule.
ISSN: 0277-5387
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