Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4666
Title: Lipase-catalyzed regioselective acylation of resorcin[4]arenes
Authors: Botta, B
Zappia, G
Tafi, Andrea 
Botta, Maurizio 
Manetti, Fabrizio 
Cernia, E
Milana, G
Palocci, C
Soro, S
DELLE MONACHE, G.
Keywords: Docking; Lipase; Molecular modeling; Resorcinarene; Transesterification
Issue Date: 2002
Project: None 
Journal: JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
Abstract: 
Immobilized lipase from Mucor miehei (RML) catalyzed the regioselective acylation of the C-2 side-chain of the C-alkyl resorcin[4]arene tetra-alcohol 1 in the 1,2-alternate form in organic solvents using vinyl acetate as acylating reagent. The influence of reaction parameters and solvent choice were also studied. Docking simulations allowed the determination of the binding geometry of 1, revealing the importance of Trp88 residue in stabilizing the Michaelis-Menten complex between enzyme and substrate.
Description: 
36891
URI: http://hdl.handle.net/20.500.12779/4666
ISSN: 1381-1177
DOI: 10.1016/S1381-1177(01)00068-6
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