Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4658
Title: alpha1-Adrenoceptor Antagonists. Rational Design, Synthesis and Biological Evaluation of New Trazodone-like Compounds
Authors: L., Betti
Botta, Maurizio 
Corelli, Federico 
M., Floridi
P., Fossa
G., Giannaccini
Manetti, Fabrizio 
G., Strappaghetti
S., Corsano
Issue Date: 2002
Project: None 
Journal: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Abstract: 
A rational design approach has been applied to synthesize a novel class of compounds with affinity for α1 adrenergic receptors (AR). Molecular structures are characterized by a benzimidazolylpyridazinone or an imidazolylpyridazinone moiety, an original fragment in the field of the arylpiperazine compounds with α1-AR blocking properties. A 1.1 nM affinity toward α1-AR was found for compound 3, the most active of this series.
Description: 
24335
URI: http://hdl.handle.net/20.500.12779/4658
ISSN: 0960-894X
DOI: 10.1016/S0960-894X(01)00772-7
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