Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4592
Title: Impact of Cu(II) and Ni(II) on a structure of chiral peptide nucleic acids having four, six and eight thymines in a peptide side chain
Authors: J., Brasun
S., Oldziej
Taddei, Maurizio 
H., Kozlowski
Issue Date: 2001
Project: None 
Journal: JOURNAL OF INORGANIC BIOCHEMISTRY
Abstract: 
The studies on binding ability of longer chiral peptide nucleic acids (having four, six and eight thymines in a peptide side chain) have shown that the interactions between the nucleic base rings within a ligand molecule have a critical impact on the complex stability. Thymines inserted in the peptide side chain interact with each other as well as with peptide back-bone increasing the structural organization of the cPNA molecule. The metal ion coordination to cPNA, on the other hand, induces a very specific ligand structure, which may have a basic impact on the cPNA self-recognition processes. (C) 2001 Elsevier Science B.V. All rights reserved.
Description: 
45995
URI: http://hdl.handle.net/20.500.12779/4592
ISSN: 0162-0134
DOI: 10.1016/S0162-0134(01)00207-0
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