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|Title:||Molecular mechanism of hydrogen peroxide conversion and activation by Cu(II)-amikacin complexes||Authors:||M., Jezowska Bojczuk
W., Meyer Klaucke
|Keywords:||XAS; copper; amikacin||Issue Date:||2001||Project:||None||Journal:||CHEMICAL RESEARCH IN TOXICOLOGY||Abstract:||
The interactions between Cu(II)-amikacin complexes [Cu(Il)-Amil and hydrogen peroxide were studied by spectroscopy (EPR, UV-vis, CD, XAS) and cyclic voltammetry. A monomer-dimer equilibrium was detected at complex concentrations above 5 mM (log K-dim = 1.84 +/- 0.03). The dimeric complex undergoes easy, although irreversible oxidation (ca. 0.5-0.6 V) to a Cu(III) species on platinum electrode. However, the monomeric complexes are able to catalyze hydrogen peroxide disproportionation reaction at pH 7.4 in a multistep process, mediated by hydroxyl radicals and involving both Cu(I)/Cu(II) and Cu(II)/Cu(III) redox pairs.
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