Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4578
Title: Synthesis, biological evaluation and pharmacophore generation of uracil, 4(3H)-pyrimidinone, and uridine derivatives as potent and selective inhibitors of parainfluenza 1 (Sendai) virus
Authors: Saladino, R
Crestini, Palamara
DANTI M., C
Manetti, Fabrizio 
Corelli, Federico 
Garaci, E
Botta, Maurizio 
Issue Date: 2001
Project: None 
Journal: JOURNAL OF MEDICINAL CHEMISTRY
Abstract: 
Several new 6-oxiranyl-, 6-oxiranylmethyluracils, and pyrimidinone derivatives, synthesized by lithiation-alkylation sequence of 1,3,6-trimethyluracil, 1,3-dimethyl-6-chloromethyluracil, and 2-alkoxy-6-methyl-4(3H)-pyrimidinones, showed a potent and selective antiviral activity against Sendai virus (SV) replication. To gain insight into the structural features required for SV inhibition activity, the new compounds were submitted to a pharmacophore generation procedure using the program Catalyst. The resulting pharmacophore model showed high correlation and predictive power. It also rationalized the relationships between structural properties and biological data of these inhibitors of SV replication.
Description: 
38016
URI: http://hdl.handle.net/20.500.12779/4578
ISSN: 0022-2623
DOI: 10.1021/jm010938i
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