Please use this identifier to cite or link to this item:
|Title:||Altered glutathione anti-oxidant metabolism during tumor progression in human renal-cell carcinoma||Authors:||Lusini, L
Tripodi, S. A.
DEL VECCHIO, MARIA TERESA
CHERUBINI DI SIMPLICIO, Paolo
|Issue Date:||2001||Project:||None||Journal:||INTERNATIONAL JOURNAL OF CANCER||Abstract:||
It has been proposed that oxidative stress develops in tumors, with important consequences for growth and progression. To investigate this hypothesis, we measured low m.w. thiols, disulfides, protein-mixed disulfides and a pool of major anti-oxidant enzymes in renal-cortex as well as renal-cell carcinoma (RCC) specimens at stages I-II and III. Our data showed (i) a significant increase in the levels of total intracellular glutathione at both tumor stages (levels were 2.6-2.8 fold higher than those in the normal renal cortex), (ii) a marked lowering of the GSH/GSSG ratio in stage I-II accompanied by a significant decrease of many GSH-dependent enzymes (i.e., GPX, GST, GGT, GR) and (iii) unchanged GSH/GSSG ratio and GSH-dependent enzyme activity in stage III with respect to normal renal cortex. These results indicate that relevant variations exist in the glutathione antioxidant system in the different stages of RCC and support the hypothesis that oxidative stress plays an important role in RCC growth and progression.
|Appears in Collections:||Publications|
Show full item record
checked on May 7, 2021
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.