Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4559
Title: Conformational search of antisense nucleotides
Authors: Stefano, Alcaro
Tafi, Andrea 
Francesco, Ortuso
Lucyna A., Woźniak
Eszter Gács, Baitz
Botta, Maurizio 
Issue Date: 2001
Project: None 
Journal: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Abstract: 
A preliminary MMFF implementation of selenium atom parameters necessary to model the nucleoside I is reported. X-ray structures of two compounds I and 2 have been used as references. Ab initio methods have been adopted for checking torsional energy profile and charge distribution. Monte Carlo calculations and energy minimization in solvation complete the conformational search. (C) 2001 Elsevier Science Ltd. All rights reserved.
Description: 
49352
URI: http://hdl.handle.net/20.500.12779/4559
ISSN: 0960-894X
DOI: 10.1016/S0960-894X(01)00401-2
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