Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4491
Title: Synthesis and Preliminary Biological Evaluation of 4,6-Disubstituted 3-Cyanopyridin-2(1H)-ones, a New Class of Calcium Entry Blockers
Authors: Manna, Chimenti
Bolasco, Bizzarri
Botta, Maurizio 
Tafi, Andrea 
Filippelli, Rossi
Issue Date: 2000
Project: None 
Journal: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Abstract: 
The preparation of 3-cyano-4,6-diaryl-pyridin-2(1H)-ones 4a-h, calcium entry blockers related to diltiazem, is described starting from 1,3-diaryl-2-propen-1-ones 5. On preliminary pharmacological tests all compounds are active and some of them show calcium antagonistic activity superior or comparable to diltiazem.
Description: 
37693
URI: http://hdl.handle.net/20.500.12779/4491
ISSN: 0960-894X
DOI: 10.1016/S0960-894X(00)00361-9
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