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|Title:||Synthesis of Enantiomerically Pure 1[(-(benzofuran-2-yl)arylmethyl]-1H-1,2,4-triazoles, Antifungal and Antiaromatase Agents||Authors:||Messina,
Racemic and enantiopure benzofuranmethanamines 5a–c have been reacted with N-Boc-3-(4-cyanophenyl)oxaziridine to give N-Boc-hydrazines 7a–c, which have in turn been transformed by deprotection and cyclisation into triazoles 4a–c, potent antiaromatase agents, in good overall yield and with high enantiomeric excess.
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