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|Title:||Novel polysaccharide hydrogels: characterization and properties||Authors:||Magnani, Agnese
|Keywords:||synthesis; polysaccharide; hydrogels; physico-chemical properties; cell adhesion||Issue Date:||2000||Project:||None||Journal:||POLYMERS FOR ADVANCED TECHNOLOGIES||Abstract:||
New chemical hydrogels, potentially suitable for biome-dical applications, have been synthesized and character-ized by 13C NMR, and FT-IR spectroscopy. Thepolysaccharide components of these hydrogels arehyaluronane, alginate and carboxymethylcellulose, whilethe novel cross-linking procedure consists of activatingthe carboxylate moieties by 2-chloro-1-methylpyridiniumiodide CMPJ and using 1,3-diaminopropane as achemical bridge. Varying the amount of CMPJ threeseries of hydrogels were obtained with different cross-linking degrees (5, 50, 100%). Their percentages weredetermined by 13C NMR and FT-IR analysis. Themorphology of the gels was studied by scanning electron-microscopy and the pore sizes were determined in orderto find a relationship with the swelling properties.Cell adhesion, using human hepatocytes, and plateletadhesion studies on the different series of cross-linkedcompounds allowed us to envisage their utilization asextracellular matrix materials and cardiovascular bio-materials.
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