Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4421
Title: Structural properties of the nickel ions in urease: novel insights into the catalytic and inhibition mechanisms
Authors: S., Ciurli
S., Benini
W. R., Rypniewski
K. S., Wilson
S., Miletti
Mangani, Stefano 
Keywords: urease; function; mechanism
Issue Date: 1999
Project: None 
Journal: COORDINATION CHEMISTRY REVIEWS
Abstract: 
This work provides a comprehensive critical summary of urease spectroscopy, crystallography, inhibitor binding, and site-directed mutagenesis, with special emphasis given to the relationships between the structural Features of the Ni-containing active site and the physico-chemical and biochemical properties of this metallo-enzyme. In addition, the recently determined structure of a complex between urease and a transition state analogue is discussed as it leads to a novel, thought-provoking proposal for the enzyme mechanism. (C) 1999 Elsevier Science S.A. All rights reserved.
Description: 
47962
URI: http://hdl.handle.net/20.500.12779/4421
ISSN: 0010-8545
DOI: 10.1016/S0010-8545(99)00093-4
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