Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4379
Title: EPR and O2- Scavenger Activity: Cu(II)-Peptide Complexes as Superoxide Dismutase Models
Authors: Pogni, Rebecca 
Baratto, Maria Camilla 
Busi, Elena 
Basosi, Riccardo 
Keywords: Peptides, Copper complexes, Superoxide dismutase models, EPR spectroscopy, Scavenger activity
Issue Date: 1999
Project: None 
Journal: JOURNAL OF INORGANIC BIOCHEMISTRY
Abstract: 
A variety of copper(lI) complexes with di-, tri- and tetra-peptides containing only glycine residues (GG, GGG and GGGG) and others containing a histidyl residue in different positions (HGG, GHG, GGH and GGHG) have been investigated. EPR parameters obtained by extensive use of computer simulation of spectra lead to reliable spin Hamiltonian EPR parameters at both room temperature and in frozen solution. The molecular orbital coefficients computed from the anisotropic EPR data and the d-d electronic energies are used to characterize different arrangements of the complexes. Estimation of the scavenger activity of the complexes due to the particular environment created by the ligands around copper is discussed in the frame of the structure-activity relationship.
Description: 
35000
URI: http://hdl.handle.net/20.500.12779/4379
ISSN: 0162-0134
DOI: 10.1016/S0162-0134(99)00012-4
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