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|Title:||Small ring constrained peptidomimetics. Synthesis of aziridine parallel beta-sheet mimetics||Authors:||S. N., Filigheddu
|Issue Date:||1998||Project:||None||Journal:||TETRAHEDRON LETTERS||Abstract:||
The synthesis of a series of novel amino acids and peptides containing an aziridine ring is described. Their preparation is based on the Gabriel-Cromwell reaction of amino acids or peptides with different 2-bromo acrylates and acrylamides. These products are constituted by a turned scaffold (the aziridine) where two parallel peptidic strands can be grown to produce a beta-sheet mimetic. (C) 1998 Elsevier Science Ltd. All rights reserved.
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