Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/4229
Title: Biocompatibility and enzymatic degradation studies on sulphated hyaluronic acid derivatives
Authors: Giovanni, Abatangelo
Barbucci, Rolando
Paola, Brun
Lamponi, Stefania 
Keywords: hyaluronic acid; sulphation; heparin.likepolysaccharides; cytotoxicity; cytocompatibility; enzymatic degradation
Issue Date: 1997
Project: None 
Journal: BIOMATERIALS
Abstract: 
Sulphated hyaluronic acids having a sulphation degree of 3.5 per disaccharide unit, HyalS3.5, were prepared with different molecular weights corresponding to 21 x 10(3), 320 x 10(3) and 3500 x 10(3). The thrombin inhibition in plasma and in the presence of purified molecules, i.e. fibrinogen, antithrombin III (AT III) and heparin cofactor II (HC II), were studied for the three different MW compounds at different concentrations. The thrombin time in plasma depended on the length of the chain, and the two lower MW HyalS3.5 inhibited thrombin both by direct aspecific interaction and via HC II, whereas the activity of the highest MW compound was mainly related to the electrostatic interaction with HC II. The inactivation of FXa serine protease was only attributed to HyalS3.5-AT III complex.
Description: 
54610
URI: http://hdl.handle.net/20.500.12779/4229
ISSN: 0142-9612
DOI: 10.1016/S0142-9612(97)00089-6
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